Chemistry

   

Comment on "Serum Albumin Binding of Structurally Diverse Neutral Organic Compounds: Data and Models"

Authors: Sierra Rayne

In their article, Endo and Goss [Chem. Res. Toxicol. 2011, 24, 2293-2301] claim to measure the bovine serum albumin water partition coefficients for 83 structurally diverse neutral organic chemicals and correlate the resulting values against corresponding octanol-water partition coefficients and polyparameter linear free energy relationship models based on descriptors for the neutral forms of each compound. However, several compounds in the authors' dataset would be significantly ionized under the experimental conditions being modeled against, and such ionization must be accounted for in any serum albumin binding modeling efforts.

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[v1] 2013-03-21 22:19:09

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