Epigenetic Effects of Cytosine Derivatives Are Caused by Their Tautomers in Hoogsteen Base Pairs

Authors: Denis A. Semyonov

Deoxycitidine in solution exists as two tautomers one of which is an “uncanonical” imino one. The latter can dominate with such derivatives as 5-methyl, 5-hydroxymethyl- and 5-formylcytosine. The imino tautomer potentially is able to form a hoosteen GC base pair. To detect such pair, it is suggested to use 1H15N NMR. Formation of GC-Hoogsteen base pair with imino tautomer of cytosine can be a reason for epigenetic effects of 5-methyl- and , 5-hydroxymethylcytosine.

Comments: 6 Pages.

Download: PDF

Submission history

[v1] 2014-09-13 21:45:39

Unique-IP document downloads: 74 times is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. will not be responsible for any consequences of actions that result from any form of use of any documents on this website.

Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.

comments powered by Disqus