Biochemistry

   

Epigenetic Effects of Cytosine Derivatives Are Caused by Their Tautomers in Hoogsteen Base Pairs

Authors: Denis A. Semyonov

Deoxycitidine in solution exists as two tautomers one of which is an “uncanonical” imino one. The latter can dominate with such derivatives as 5-methyl, 5-hydroxymethyl- and 5-formylcytosine. The imino tautomer potentially is able to form a hoosteen GC base pair. To detect such pair, it is suggested to use 1H15N NMR. Formation of GC-Hoogsteen base pair with imino tautomer of cytosine can be a reason for epigenetic effects of 5-methyl- and , 5-hydroxymethylcytosine.

Comments: 6 Pages.

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Submission history

[v1] 2014-09-13 21:45:39

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