Hysteresis and Negative Resistance Regimes in Membrane Perturbations by Chrysin

Authors: Sai Venkatesh Balasubramanian

The growing concerns about pro-oxidant nature and toxicity during interaction of flavonoids such as chrysin and associated metal complexes with the cell membrane has led to investigations on membrane perturbations by the same. However, the Cyclic Voltammetry (CV) results show signs indicative of a hysteesis behavior. Taking cue from this, the present work is directed at a nonlinear analysis and characterization of the CV results of membrane perturbations by Chrysin and its copper and iron complexes. Plots of the Voltage-Resistance (V-R) and Voltage-Capacitance (V-C) relations show that while the capacitance is constant independent of voltage, the V-R behavior shows an interesting Hysteresis pattern with negative resistance peaks being seen. Presence of dosage-independent chaos is ascertained using the Lyapunov Exponent. The present work offers an insight into the nonlinear behavior underlying the mechanics of flavonoid-cell membrane interaction and might be the first step in a series of studies focused on the role of nonlinearity and chaos on toxicity.

Comments: 5 Pages.

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[v1] 2015-10-27 21:11:17

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