History and Philosophy of Physics

   

How my 1983 Idea for a Super-Resolving Single-Molecule Fluorescence Microscope Independently Won the 2014 Nobel Prize in Chemistry

Authors: Vladimir F. Tamari

This paper documents how one of the author's inventions, sketched in 1983 in his notebook and published nowhere else, came to be independently developed and won Eric Betzig and others the 2014 Nobel Prize in Chemistry. The concept was to take multiple sequences of images of the same object, randomly lit by fluorescent light one molecule at a time, digitally process these images and combine them in a final image so sharp it goes beyond the theoretical resolution limits set by Abbe for microscopes. As confirmed by the company's present CEO the basic idea was mentioned in an awards application to Carl Zeiss company in1995. Now Zeiss is manufacturing microscopes based on the same principle, revolutionizing biological and medical research because it allows the imaging of live cells in unprecedented finely resolved detail.

Comments: 13 Pages.

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[v1] 2016-01-12 05:16:11

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