A new method was established for simultaneous estimation of Tolperisone and Diclofenac sodium by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Tolperisone and Diclofenac sodium by using Agilent C18 column flow rate was 1ml/min, mobile phase ratio was (70:30 v/v) ACN: phosphate buffer pH 3 (pH was adjusted with orthophosphoricacid), detection wavelength was 240nm.The retention times were found to be 4.645 mins and 2.242 mins. The % purity of Tolperisone and Diclofenac sodium was found to be 100.3% and 99.27% respectively. The analytical method was validated according to ICH guidelines. The precision study was precision, robustness and repeatability. LOD value was 2.17 and 0.0372 and LOQ value was 6.60 and 0.1125 respectively. You can submit your Manuscripts at: https://symbiosisonlinepublishing.com/submitManuscript.php
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[v1] 2017-08-28 02:38:13
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