Gastric Cancer and Epstein-Barr Virus Infection. a Systematic Review of Ish Based Studies.

Authors: Ilija Barukčić

Background: Epstein-Barr virus (EBV) has an important role in the oncogenesis of several malignant diseases. Reports demonstrated even the presence of Epstein-Barr virus in gastric carcinoma (GC). However, the pathogenic role of EBV in CG is uncertain. The present investigation was carried out to investigate a possible causal relationship between GC and EBV. Statistical Analysis: The method of the conditio sine qua non relationship was used to proof the hypothesis whether gastric cancer is a necessary condition (a conditio sine qua non) of the presence of EBV in human gastric tissues. In other words, without GC no EBV positivity in human stomach. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause effect relationship between gastric cancer and EBV. Significance was indicated by a p-value (two sided) of less than 0.05. Results: In toto 26 ISH based studies with a sample size of N = 11860 were re-analyzed. All the studies analyzed support the null-hypothesis without GC no EBV positivity in human gastric tissues. In other words, gastric cancer itself is a conditio sine qua on of EBV positivity in human gastric cancer while the cause effect relationship between gastric cancer and EBV was highly significant. Conclusions: Epstein-Barr virus in neither a cause or the cause of human gastric cancer. Keywords: Gastric cancer, Epstein-Barr virus, cause effect relationship, causality

Comments: 22 Pages. Copyright © 2018 by Ilija Barukčić, Jever, Germany. Published by

Download: PDF

Submission history

[v1] 2018-07-13 13:08:49

Unique-IP document downloads: 5 times is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. will not be responsible for any consequences of actions that result from any form of use of any documents on this website.

Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.

comments powered by Disqus