A simple, sensitive, precise, accurate and economical spectrophotometric method of analysis for lurasidone in bulk form was developed and validated. The method employed acetonitrile as solvent and the drug shows maximum absorbance at 263 nm. The absorbance was found to increase linearly with increasing concentration of lurasidone, which is corroborated by the calculated correlation coefficient value (r2 = 0.999). The linear regression analysis data for the calibration plot showed good linear relationship with in the concentration range of 10 – 60 μg/ml. The limit of detection and limit of quantitation were found to be 1.25316 μg/ ml and 3.797468 μg /ml respectively. This method was tested and validated for various parameters according to ICH guidelines. The results demonstrated that the procedure is accurate, precise and reproducible (R.S.D. < 2 %).
Comments: 9 Pages. OK
[v1] 2019-05-19 05:50:15
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