Authors: Ilija Barukčić
Comments: 15 pages. Copyright © 2018 by Ilija Barukčić, Jever, Germany. Published by:.
Objective: The relationship between Human cytomegalovirus (HCMV) and glioblastoma multiforme (GBM) is investigated.
Methods: A systematic review and re-analysis of some impressive key studies was conducted aimed to answer the following question. Is there a cause-effect relationship between HCMV and GBM? The method of the conditio sine qua non relationship was used to proof the hypothesis whether the presence of HCMV guarantees the presence of GBM. In other words, without HCMV no GBM The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause-effect relationship between HCMV and GBM. Significance was indicated by a p-value of less than 0.05.
Results: The studies analysed were able to provide strict evidence that HCMV is a necessary condition (a conditio sine qua non) of GBM. Furthermore, the cause-effect relationship between HCMV and GBM (k = +1, p value < 0,0001) was highly significant.
Conclusion: Without HCMV no GBM. HCMV is the cause of GBM.
Keywords: Cytomegalovirus, Glioblastoma multiforme, Causal relationship
Authors: Raymond HV Gallucci
Comments: 50 Pages. Adds reference to recent publication.
Before proceeding, and lest opponents of nuclear power think this paper lends support to their efforts to shut down the nuclear industry, I must state the following. NFPA 805 will have been successful in that plants transitioning to it will be as safe as or safer than prior to transition. Plants that made no changes will have at least assessed their fire risks and be more knowledgeable of potential weaknesses that could compromise safety. Having found none, they will not have the need for changes. Plants that made effective changes will be safer than before. If you are one who believes the end justifies the means, then this “bottom line” is all that matters and you need read no further. However, if you are one who believes the means are also important, then you are the audience that I address.
I am in no way contending that adoption of NFPA 805 compromised safety – I, too, believe that plants will be as safe or safer as a result of the transition. Why I wrote this paper is to express frustration over the “compromises” allowed by the NRC, and the “short-cuts” and “deviations” taken by the nuclear industry, to fulfill the promise of a “sea change” in fire protection at nuclear power plants through risk-informed, performance-based regulation. And, while no diminution of safety will have occurred, it is possible there were missed opportunities to improve safety if changes might have been made, or different changes substituted for those that were made, if not for these “compromises,” “short-cuts” and “deviations.”
I must confess to being guilty of false optimism in December 2006 when I wrote “perhaps the single achievement most responsible for the improved regulatory environment for fire protection at commercial nuclear power plants has been the modification to 10CFR50.48 that allows licensees to ‘maintain a fire protection program that complies with NFPA 805 as an alternative to complying with [past, purely deterministic regulations]’” (Gallucci, “Thirty-Three Years of Regulating Fire Protection at Commercial U.S. Nuclear Power Plants: Dousing the Flames of Controversy,” Fire Technology, Vol. 45, pp. 355-380, 2009).
Authors: Ilija Barukčić
Comments: 26 pages. Copyright © 2018 by Ilija Barukcic, Jever, Germany. Published by: ...
BACKGROUND: Cytomegalovirus (CMV) infection has been supposed to play an important role in the pathogenesis of atherosclerosis (AS). Although many authors proved the presence of viral DNA in arterial wall tissue, the role of CMV in the origin and progress of athero-sclerosis still remains unclear and no definite consensus has been reached. Whether CMV may be involved in the development of AS has not yet been established. METHODS: The purpose of this study was to investigate whether CMV and AS are causally related. Literature was searched through the electronic database PubMed. Data were accurately assessed and analyzed. RESULTS: The meta-analysis results showed that CMV infection and AS are causally connected. CONCLUSIONS: Cytomegalovirus is the cause of atherosclerosis. Keywords Cytomegalovirus, atherosclerosis, causal relationship