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1807 Submissions

[2] viXra:1807.0249 [pdf] submitted on 2018-07-13 13:08:49

Gastric Cancer and Epstein-Barr Virus Infection. a Systematic Review of Ish Based Studies.

Authors: Ilija Barukčić
Comments: 22 Pages. Copyright © 2018 by Ilija Barukčić, Jever, Germany. Published by

Background: Epstein-Barr virus (EBV) has an important role in the oncogenesis of several malignant diseases. Reports demonstrated even the presence of Epstein-Barr virus in gastric carcinoma (GC). However, the pathogenic role of EBV in CG is uncertain. The present investigation was carried out to investigate a possible causal relationship between GC and EBV. Statistical Analysis: The method of the conditio sine qua non relationship was used to proof the hypothesis whether gastric cancer is a necessary condition (a conditio sine qua non) of the presence of EBV in human gastric tissues. In other words, without GC no EBV positivity in human stomach. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause effect relationship between gastric cancer and EBV. Significance was indicated by a p-value (two sided) of less than 0.05. Results: In toto 26 ISH based studies with a sample size of N = 11860 were re-analyzed. All the studies analyzed support the null-hypothesis without GC no EBV positivity in human gastric tissues. In other words, gastric cancer itself is a conditio sine qua on of EBV positivity in human gastric cancer while the cause effect relationship between gastric cancer and EBV was highly significant. Conclusions: Epstein-Barr virus in neither a cause or the cause of human gastric cancer. Keywords: Gastric cancer, Epstein-Barr virus, cause effect relationship, causality
Category: Statistics

[1] viXra:1807.0036 [pdf] submitted on 2018-07-01 09:04:41

Sunburn and Malignant Melanoma

Authors: Ilija Barukčić
Comments: 25 Pages. pp. 25. Copyright © 2018 by Ilija Barukčić, Jever, Germany. Published by

Background: Unfortunately, despite recent scientific advances the cause of malignant melanoma is not identified. The incidence of malignant melanoma increases and malignant melanoma continues to represent a significant individual and public health challenge. Objectives: In this systematic review studies were re-analyzed so that some new inferences can be drawn. Statistical Analysis: The method of the conditio per quam relationship was used to proof the hypothesis whether the presence of human papillomavirus guarantees the presence of malignant melanoma. In other words, if human papillomavirus is present, then malignant melanoma is present too. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause effect relationship between human papillomavirus and malignant melanoma. Significance was indicated by a p-value of less than 0.05. Results: The studies analyzed support the null-hypothesis that the presence of human papillomavirus guarantees the presence of malignant melanoma. In other words, human papillomavirus is a conditio per quam of malignant melanoma while the cause effect relationship between human papillomavirus and malignant melanoma was highly significant. Conclusions: Human papillomavirus is a sufficient condition of malignant melanoma. Human papillomavirus is a cause of malignant melanoma. Keywords: Human papillomavirus, malignant melanoma, cause effect relationship, causality
Category: Statistics