Physics of Biology

2002 Submissions

[63] viXra:2002.0575 [pdf] submitted on 2020-02-28 11:43:12

Nonspherical Viral Nanocages

Authors: George Rajna
Comments: 52 Pages.

Nevertheless, protein nanocages have great potential as building blocks to create more functional materials. [31] In a recent study in mice, researchers found a way to deliver specific drugs to parts of the body that are exceptionally difficult to access. [30] Now MIT engineers have come up with a tissueengineering design that may enable flexible range of motion in injured tendons and muscles during healing. [29] Researchers at MIT, working with surgeons and oncologists at Massachusetts General Hospital (MGH), have now developed a way to improve the accuracy of this surgery, called debulking. [28] Scientists at the University of Bristol have invented a new technology that could lead to the development of a new generation of smart surgical glues and dressings for chronic wounds. [27] Elaborate molecular networks inside living cells enable them to sense and process many signals from the environment to perform desired cellular functions. [26] RNA sequencing is a technique used to analyze entire genomes by looking at the expression of their genes. [25] Researchers from the University of Chicago have developed a high-throughput RNA sequencing strategy to study the activity of the gut microbiome. [24] Today a large international consortium of researchers published a complex but important study looking at how DNA works in animals. [23] Asymmetry plays a major role in biology at every scale: think of DNA spirals, the fact that the human heart is positioned on the left, our preference to use our left or right hand ... [22] Scientists reveal how a 'molecular machine' in bacterial cells prevents fatal DNA twisting, which could be crucial in the development of new antibiotic treatments. [21] In new research, Hao Yan of Arizona State University and his colleagues describe an innovative DNA HYPERLINK "https://phys.org/tags/walker/" walker, capable of rapidly traversing a prepared track. [20]
Category: Physics of Biology

[62] viXra:2002.0566 [pdf] submitted on 2020-02-28 02:06:15

Nanoparticles Risks in Medical Application

Authors: George Rajna
Comments: 37 Pages.

However, the rising popularity of nanobiomaterials (NBMs) also raises questions about their potential adverse effects on the environment after excretion and release. [23] Nuclear technology companies Phoenix and SHINE Medical Technologies have achieved a new world record for a nuclear fusion reaction in a steady-state system, the strongest of its kind ever produced on Earth. [22] Bacterial systems are some of the simplest and most effective platforms for the expression of recombinant proteins. [21]
Category: Physics of Biology

[61] viXra:2002.0563 [pdf] submitted on 2020-02-28 08:02:07

Oncology Neglects Stray Radiation

Authors: George Rajna
Comments: 39 Pages.

Researchers in the US and Germany modified a treatment planning system (TPS)-the software used to predict patient dose distribution-to include unwanted doses from scattered and leaked radiation. [23] Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a technique to observe how radiation damages molecules over time frames of just one quadrillionth of a second-or a femtosecond. [22] DNA forensics is a powerful tool, yet it presents a computational scaling problem when it is improved and expanded for complex samples (those containing DNA from more than one individual) and kinship analysis. [21] In a surprising marriage of science and art, researchers at MIT have developed a system for converting the molecular structures of proteins, the basic building blocks of all living beings, into audible sound that resembles musical passages. [20] Inspired by ideas from the physics of phase transitions and polymer physics, researchers in the Divisions of Physical and Biological Sciences at UC San Diego set out specifically to determine the organization of DNA inside the nucleus of a living cell. [19] Scientists from the National Institute of Standards and Technology (NIST) and the University of Maryland are using neutrons at Oak Ridge National Laboratory (ORNL) to capture new information about DNA and RNA molecules and enable more accurate computer simulations of how they interact with everything from proteins to viruses. [18] The DNA molecules are chiral, which means they can exist in two forms which are mirror images, like a left and right hand. The phenomenon was dubbed "chiral induced spin selectivity" (CISS), and over the last few years, several experiments were published allegedly showing this CISS effect, even in electronic devices. [17] Chemist Ivan Huc finds the inspiration for his work in the molecular principles that underlie biological systems. [16] What makes particles self-assemble into complex biological structures? [15]
Category: Physics of Biology

[60] viXra:2002.0555 [pdf] submitted on 2020-02-27 11:39:47

Protein and Quantum Dots

Authors: George Rajna
Comments: 50 Pages.

Scientists at the National Research Nuclear University MEPhI (Russia) have created a new type of solar panel based on hybrid material consisting of quantum dots (QDs) and photosensitive protein. [29] "Maybe this will tell us a bit more about how macrophages associated with tumors and infection can suppress a T cell response," he says. [28] Sunlight is essential for all life, and living organisms have evolved to sense and respond to light. [27] Using X-ray laser technology, a team led by researchers of the Paul Scherrer Institute PSI has recorded one of the fastest processes in biology. [26] A Virginia Commonwealth University researcher has developed a procedure for identifying the source of cells present in a forensic biological sample that could change how cell types are identified in samples across numerous industries. [25] In work at the National Institute of Standards and Technology (NIST) and the University of Maryland in College Park, researchers have devised and demonstrated a new way to measure free energy. [24] A novel technique developed by researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) will help shine new light on biological questions by improving the quality and quantity of information that can be extracted in fluorescence microscopy. [23] Micro-computed tomography or "micro-CT" is X-ray imaging in 3-D, by the same method used in hospital CT (or "CAT") scans, but on a small scale with massively increased resolution. [22] A new experimental method permits the X-ray analysis of amyloids, a class of large, filamentous biomolecules which are an important hallmark of diseases such as Alzheimer's and Parkinson's. [12] Thumb through any old science textbook, and you'll likely find RNA described as little more than a means to an end, a kind of molecular scratch paper used to construct the proteins encoded in DNA. [20]
Category: Physics of Biology

[59] viXra:2002.0528 [pdf] submitted on 2020-02-26 02:53:59

Laser-Based Medical Imaging

Authors: George Rajna
Comments: 28 Pages.

Wang, Bren Professor of Medical Engineering and Electrical Engineering, has now further advanced photoacoustic imaging technology with what he calls Photoacoustic Topography Through an Ergodic Relay (PATER), which aims to simplify the equipment required for imaging of this type. [16] Researchers supported by the EU-funded photonics innovation incubator ACTPHAST 4.0 have introduced "a swept light source technology that makes it possible to take full 3-D OCT [optical coherence tomography] images of the eye," says a news release posted on the project website. [15] A new 3-D particle-in-cell (PIC) simulation tool developed by researchers from Lawrence Berkeley National Laboratory and CEA Saclay is enabling cutting-edge simulations of laser/plasma coupling mechanisms that were previously out of reach of standard PIC codes used in plasma research. [14]
Category: Physics of Biology

[58] viXra:2002.0525 [pdf] submitted on 2020-02-26 04:01:49

Comments on the Origin and Spread of the 2019 Coronavirus

Authors: N Chandra Wickramasinghe, Edward J Steele, Reginald M Gorczynski, Robert Temple, Gensuke Tokoro, Jiangwen Qu, Daryl H Wallis, Brig Klyce
Comments: 4 Pages.

We propose that the new coronavirus which first appeared in the Hubei province of China was probably linked to the arrival of a pure culture of the virus contained in cometary debris that was dispersed over a localised area of the planet namely China. The sighting of a fireball some 2000 kilometers north of Wuhan on 11 October 2019 followed shortly after with the first recorded cases in Hubei is suggestive of a causal link. Gene sequencing data of the virus that show little or no genetic variations between isolates, combined with available epidemiological data point to the predominance of a transmission process directly from an “infected” environment, with person- to-person transmission playing a comparatively weaker secondary role. The facts relating to this epidemic are discussed and placed in the context of other pandemics that have been recorded throughout history.
Category: Physics of Biology

[57] viXra:2002.0518 [pdf] submitted on 2020-02-26 07:30:50

Cold Plasma and Immunotherapy

Authors: George Rajna
Comments: 30 Pages.

An inter-disciplinary research team headed up at the University of California, Los Angeles (UCLA) has pioneered a new, minimally invasive approach to skin cancer treatment. [17] Wang, Bren Professor of Medical Engineering and Electrical Engineering, has now further advanced photoacoustic imaging technology with what he calls Photoacoustic Topography Through an Ergodic Relay (PATER), which aims to simplify the equipment required for imaging of this type. [16]
Category: Physics of Biology

[56] viXra:2002.0510 [pdf] submitted on 2020-02-26 09:58:29

Revolutionize Fluorescent Microscopy

Authors: George Rajna
Comments: 70 Pages.

EPFL scientists have developed a new type of microscope slide that can boost the amount of light in fluorescence microscopy by a factor of up to 25. [46] Selecting the most effective molecules for drug delivery is often a trial-and-error process, but Cornell engineers are providing some precision thanks to a technique that reveals the performance of those molecules inside living cells. [45] Now, researchers at MIT and elsewhere have developed a system to deliver medical treatments that can be released at precise times, minimally-invasively, and that ultimately could also deliver those drugs to specifically targeted areas such as a specific group of neurons in the brain. [44] Gene editing technology is a technology that eliminates the underlying causes of and treats diseases by removing specific genesor editing genes to restore their normal function. In particular, CRISPR gene editing technology is now commonly used for immunotherapy by correcting the genes of immune cells to induce them to attack cancer cells selectively. [43]
Category: Physics of Biology

[55] viXra:2002.0499 [pdf] submitted on 2020-02-25 02:38:48

Nanoparticles Straight to Tumors

Authors: George Rajna
Comments: 64 Pages.

An interdisciplinary team of researchers at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and FU Berlin has made important progress in this area: the scientists have produced tiny nanoparticles that are designed to specifically target cancer cells. [34] Another collaborative project from a nanoparticles expert at The University of Texas at Arlington has yielded promising results in the search for more effective, targeted cancer treatments. [33] Automated radiotherapy planning is a boon for medical physicists and dosimetrists, radiotherapy departments, and patients themselves – according to a team at Cone Health Cancer Center. [32]
Category: Physics of Biology

[54] viXra:2002.0495 [pdf] submitted on 2020-02-25 07:32:25

Smart Senses Bacterial Infections

Authors: George Rajna
Comments: 31 Pages.

Technologies like this could contribute significantly to the fight against antimicrobial resistance. [20] For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment. [19] It's called gene editing, and University of Alberta researchers have just published a game-changing study that promises to bring the technology much closer to therapeutic reality. [18]
Category: Physics of Biology

[53] viXra:2002.0488 [pdf] submitted on 2020-02-24 11:57:14

Coronavirus is Not Alone

Authors: George Rajna
Comments: 67 Pages.

When diseases reinforce each other, they rapidly accelerate through the population, then fizzle out as they run out of new hosts. [39] It's no coincidence that some of the worst viral disease outbreaks in recent years-SARS, MERS, Ebola, Marburg and likely the newly arrived 2019-nCoV virus-originated in bats. [38] An interdisciplinary team of researchers at Colorado State University has used computational chemistry, biochemistry and virology to uncover new information on how viruses such as West Nile, dengue and Zika replicate. [37] David Baker, Professor of Biochemistry and Director of the Institute for Protein Design at the University of Washington will speak about how algorithmic processes such as de novo design predict protein structures, protein folding mechanisms, and new protein functions. [36] A research team at Kobe University has developed a method of artificially controlling the anchorage position of target proteins in engineered baker's yeast (Saccharomyces cerevisiae). [35] Scientists have found a new way to home in on the proteins covering a particular cell's surface. The feat offers insight into how brain cells form intricate networks during development. [34]
Category: Physics of Biology

[52] viXra:2002.0476 [pdf] submitted on 2020-02-24 06:03:33

Neutrons for Dental Restorations

Authors: George Rajna
Comments: 24 Pages.

Neutron scattering research provides insights that may lead to the development of novel materials for implant dentistry, he said. [14] Coupled with SNS, the world's most powerful pulsed accelerator-based neutron source, VENUS will be the only open research facility platform in the US to provide time-of-flight neutron imaging capabilities to users from academia and industry. [13] A spallation neutron source has been used by physicists in Japan to search for possible violations of the inverse square law of gravity. [12] Physicists have proposed a way to test quantum gravity that, in principle, could be performed by a laser-based, table-top experiment using currently available technology. [11] Now however, a new type of materials, the so-called Weyl semimetals, similar to 3-D graphene, allow us to put the symmetry destructing quantum anomaly to work in everyday phenomena, such as the creation of electric current. [10] Physicist Professor Chunnong Zhao and his recent PhD students Haixing Miao and Yiqiu Ma are members of an international team that has created a particularly exciting new design for gravitational wave detectors. [9] A proposal for a gravitational-wave detector made of two space-based atomic clocks has been unveiled by physicists in the US. [8] The gravitational waves were detected by both of the twin Laser Interferometer Gravitational-Wave Observatory (LIGO) detectors, located in Livingston, Louisiana, and Hanford, Washington, USA. [7] A team of researchers with the University of Lisbon has created simulations that indicate that the gravitational waves detected by researchers with the LIGO project, and which are believed to have come about due to two black holes colliding, could just have easily come from another object such as a gravaster (objects which are believed to have their insides made of dark energy) or even a wormhole. In their paper published in Physical Review Letters, the team describes the simulations they created, what was seen and what they are hoping to find in the future. [6] In a landmark discovery for physics and astronomy, international scientists said Thursday they have glimpsed the first direct evidence of gravitational waves, or ripples in space-time, which Albert Einstein predicted a century ago. [5] Scientists at the National Institute for Space Research in Brazil say an undiscovered type of matter could be found in neutron stars (illustration shown). Here matter is so dense that it could be 'squashed' into strange matter. This would create an entire 'strange star'-unlike anything we have seen. [4] The changing acceleration of the electrons explains the created negative electric field of the magnetic induction, the electromagnetic inertia, the changing relativistic mass and the Gravitational Force, giving a Unified Theory of the physical forces. Taking into account the Planck Distribution Law of the electromagnetic oscillators also, we can explain the electron/proton mass rate and the Weak and Strong Interactions.
Category: Physics of Biology

[51] viXra:2002.0471 [pdf] submitted on 2020-02-24 08:40:10

DNA Nanostructures for Future Missions

Authors: George Rajna
Comments: 56 Pages.

DNA nanostructures such as self-assembling DNA origami that fold into defined shapes are promising vehicles for the delivery of drugs and diagnostics, and different vaccination strategies. [33] According to the Mayo Clinic, about 20% of breast cancers make abnormally high levels of a protein called human epidermal growth factor receptor 2 (HER2). [32] A nanotechnology treatment derived from bone marrow stem cells has reversed multiple sclerosis symptoms in mice and could eventually be used to help humans, according to a new study led by University of California, Irvine researchers. [31]
Category: Physics of Biology

[50] viXra:2002.0459 [pdf] submitted on 2020-02-23 04:58:55

Brain Cells Protect Muscles

Authors: George Rajna
Comments: 54 Pages.

University of California, Berkeley, scientists have now found brain cells that help clean up these tangles and prolong life—at least in worms (Caenorhabditis elegans) and possibly mice. [35] University of Central Florida researchers are helping to close the gap separating human and machine minds. [34] Brain-machine interfaces provide one way to connect with this puzzling organ system, including the brain. [33]
Category: Physics of Biology

[49] viXra:2002.0455 [pdf] submitted on 2020-02-23 06:49:08

Misfolded Proteins Identified

Authors: George Rajna
Comments: 50 Pages.

A new article by the Oxidative Stress and Cell Cycle research group at UPF identifies the main strategy of cells to deal with the accumulation of misfolded proteins. [34] These will then produce the proteins themselves, without the cell functions being disturbed: cells, structures or their activities thus become visible under the microscope. [33] Measuring optical blood flow in the resting human brain to detect spontaneous activity has for the first time been demonstrated by Wright State University imaging researchers, holding out promise for a better way to study people with autism, Alzheimer's and depression. [32]
Category: Physics of Biology

[48] viXra:2002.0453 [pdf] submitted on 2020-02-23 07:21:41

DNA-Tagging of Disease Signatures

Authors: George Rajna
Comments: 35 Pages.

Researchers can uncover how proteins interact with other proteins with far greater sensitivity and in a more natural context than conventional methods, thanks to an analytic technique developed by a RIKEN team. [22] Histones are proteins that regulate the unwinding of DNA in the cell nucleus and the expression of genes based on chemical modifications or "marks" that are placed on their tails. [21] Now, in a new paper published in Nature Structural & Molecular Biology, Mayo researchers have determined how one DNA repair protein gets to the site of DNA damage. [20] A microscopic thread of DNA evidence in a public genealogy database led California authorities to declare this spring they had caught the Golden State Killer, the rapist and murderer who had eluded authorities for decades. [19] Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like structure. [18] An LMU team now reveals the inner workings of a molecular motor made of proteins which packs and unpacks DNA. [17] Chemist Ivan Huc finds the inspiration for his work in the molecular principles that underlie biological systems. [16] What makes particles self-assemble into complex biological structures? [15] Scientists from Moscow State University (MSU) working with an international team of researchers have identified the structure of one of the key regions of telomerase-a so-called "cellular immortality" ribonucleoprotein. [14] Researchers from Tokyo Metropolitan University used a light-sensitive iridium-palladium catalyst to make "sequential" polymers, using visible light to change how building blocks are combined into polymer chains. [13] Researchers have fused living and non-living cells for the first time in a way that allows them to work together, paving the way for new applications. [12]
Category: Physics of Biology

[47] viXra:2002.0449 [pdf] submitted on 2020-02-23 07:55:10

Transporter Mutation Cell Energy

Authors: George Rajna
Comments: 45 Pages.

Eric Delpire, Ph.D., and colleagues recently discovered that a patient suffering from multiorgan failure had a mutation in the gene encoding NKCC1. [26] A Virginia Commonwealth University researcher has developed a procedure for identifying the source of cells present in a forensic biological sample that could change how cell types are identified in samples across numerous industries. [25] In work at the National Institute of Standards and Technology (NIST) and the University of Maryland in College Park, researchers have devised and demonstrated a new way to measure free energy. [24] A novel technique developed by researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) will help shine new light on biological questions by improving the quality and quantity of information that can be extracted in fluorescence microscopy. [23] Micro-computed tomography or "micro-CT" is X-ray imaging in 3-D, by the same method used in hospital CT (or "CAT") scans, but on a small scale with massively increased resolution. [22] A new experimental method permits the X-ray analysis of amyloids, a class of large, filamentous biomolecules which are an important hallmark of diseases such as Alzheimer's and Parkinson's. [12] Thumb through any old science textbook, and you'll likely find RNA described as little more than a means to an end, a kind of molecular scratch paper used to construct the proteins encoded in DNA. [20] Just like any long polymer chain, DNA tends to form knots. Using technology that allows them to stretch DNA molecules and image the behavior of these knots, MIT researchers have discovered, for the first time, the factors that determine whether a knot moves along the strand or "jams" in place. [19] Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like structure. [18]
Category: Physics of Biology

[46] viXra:2002.0448 [pdf] submitted on 2020-02-23 08:12:30

Antibiotics in Animals

Authors: George Rajna
Comments: 43 Pages.

A special issue of Animal Health Research Reviews turns the spotlight on the science underlying this growing crisis—looking at the evidence base for using antibiotics to prevent illness in beef and dairy cattle, swine, and broiler poultry. [27] According to the World Health Organization, one of the biggest health threats around the world is antibiotic-resistant bacteria. [26] Researchers at the University of Illinois at Chicago have identified a molecular switch that causes immune cells called macrophages to clean up cellular debris caused by infections instead of contributing to inflammation and tissue injury. [25]
Category: Physics of Biology

[45] viXra:2002.0400 [pdf] submitted on 2020-02-21 04:25:24

Particle Therapy Accuracy

Authors: George Rajna
Comments: 50 Pages.

Ion beam radiotherapy offers precision dose deposition, with a low entrance dose increasing to a maximum at the Bragg peak and then falling off sharply. [32] Researchers at Aalto University have discovered a surprising phenomenon that changes how we think about how sound can move particles. [31] Large-scale plasmonic metasurfaces could find use in flat panel displays and other devices that can change colour thanks to recent work by researchers at the University of Cambridge in the UK. [30] Particles in solution can grow, transport, collide, interact, and aggregate into complex shapes and structures. [29] Lawrence Livermore National Laboratory (LLNL) researchers are working to make better electronic devices by delving into the way nanocrystals are arranged inside of them. [28] Self-assembly and crystallisation of nanoparticles (NPs) is generally a complex process, based on the evaporation or precipitation of NP-building blocks. [27] New nanoparticle-based films that are more than 80 times thinner than a human hair may help to fill this need by providing materials that can holographically archive more than 1000 times more data than a DVD in a 10-by-10-centimeter piece of film. [26] Researches of scientists from South Ural State University are implemented within this area. [25] Following three years of extensive research, Hebrew University of Jerusalem (HU) physicist Dr. Uriel Levy and his team have created technology that will enable computers and all optic communication devices to run 100 times faster through terahertz microchips. [24] When the energy efficiency of electronics poses a challenge, magnetic materials may have a solution. [23]
Category: Physics of Biology

[44] viXra:2002.0399 [pdf] submitted on 2020-02-21 04:46:31

Ordered Assembly of Alternating Peptides

Authors: George Rajna
Comments: 52 Pages.

A team of researchers has verified that it is possible to engineer two-layered nanofibers consisting of an ordered row of alternating peptides, and has also determined what makes these peptides automatically assemble into this pattern. [33] Ion beam radiotherapy offers precision dose deposition, with a low entrance dose increasing to a maximum at the Bragg peak and then falling off sharply. [32] Researchers at Aalto University have discovered a surprising phenomenon that changes how we think about how sound can move particles. [31] Large-scale plasmonic metasurfaces could find use in flat panel displays and other devices that can change colour thanks to recent work by researchers at the University of Cambridge in the UK. [30] Particles in solution can grow, transport, collide, interact, and aggregate into complex shapes and structures. [29] Lawrence Livermore National Laboratory (LLNL) researchers are working to make better electronic devices by delving into the way nanocrystals are arranged inside of them. [28] Self-assembly and crystallisation of nanoparticles (NPs) is generally a complex process, based on the evaporation or precipitation of NP-building blocks. [27] New nanoparticle-based films that are more than 80 times thinner than a human hair may help to fill this need by providing materials that can holographically archive more than 1000 times more data than a DVD in a 10-by-10-centimeter piece of film. [26] Researches of scientists from South Ural State University are implemented within this area. [25] Following three years of extensive research, Hebrew University of Jerusalem (HU) physicist Dr. Uriel Levy and his team have created technology that will enable computers and all optic communication devices to run 100 times faster through terahertz microchips. [24] When the energy efficiency of electronics poses a challenge, magnetic materials may have a solution. [23]
Category: Physics of Biology

[43] viXra:2002.0359 [pdf] submitted on 2020-02-19 03:53:28

SR-FACT Microscopy Cellular Organelle

Authors: George Rajna
Comments: 61 Pages.

SR-FACT visualizes both the cellular landscape and the molecular identity of live cells. [38] Using a familiar tool in a way it was never intended to be used opens up a whole new method to explore materials, report UConn researchers in Proceedings of the National Academy of Science. [37] "We put the optical microscope under a microscope to achieve accuracy near the atomic scale," said NIST's Samuel Stavis, who served as the project leader for these efforts. [36] Researchers have designed an interferometer that works with magnetic quasiparticles called magnons, rather than photons as in conventional interferometers. [35] A technique to manipulate electrons with light could bring quantum computing up to room temperature. [34] The USTC Microcavity Research Group in the Key Laboratory of Quantum Information has perfected a 4-port, all-optically controlled non-reciprocal multifunctional photonic device based on a magnetic-field-free optomechanical resonator. [33] To address this technology gap, a team of engineers from the National University of Singapore (NUS) has developed an innovative microchip, named BATLESS, that can continue to operate even when the battery runs out of energy. [32] Stanford researchers have developed a water-based battery that could provide a cheap way to store wind or solar energy generated when the sun is shining and wind is blowing so it can be fed back into the electric grid and be redistributed when demand is high. [31] Researchers at AMOLF and the University of Texas have circumvented this problem with a vibrating glass ring that interacts with light. They thus created a microscale circulator that directionally routes light on an optical chip without using magnets. [30] Researchers have discovered three distinct variants of magnetic domain walls in the helimagnet iron germanium (FeGe). [29] Magnetic materials that form helical structures-coiled shapes comparable to a spiral staircase or the double helix strands of a DNA molecule-occasionally exhibit exotic behavior that could improve information processing in hard drives and other digital devices. [28]
Category: Physics of Biology

[42] viXra:2002.0351 [pdf] submitted on 2020-02-19 08:06:44

Sensors Enhancing Human Touch

Authors: George Rajna
Comments: 45 Pages.

The sensor has remarkable sensitivity, allowing the wearer to detect the light brush of a feather, the touch of a flower petal, water droplets falling on a finger and even a wire too small to be seen. [28] Imagine a future technology that would provide instant access to the world's knowledge and artificial intelligence, simply by thinking about a specific topic or question. [27] Just like living ecosystems, web services form a complex artificial system consisting of tags and the user-generated media associated with them, such as photographs, movies and web pages. [26]
Category: Physics of Biology

[41] viXra:2002.0350 [pdf] submitted on 2020-02-19 08:34:32

Nanomaterials for DNA Diagnostics

Authors: George Rajna
Comments: 33 Pages.

Led by MIPT's Maxim Nikitin, the team published a paper in ACS Nano, presenting a smart material with unique properties, which holds promise for express DNA analysis and next-generation drugs against cancer and other serious diseases. [16] IBS scientists have reported a novel targeting strategy that allows deep tumor penetration of drug-loaded nanoparticles. [15] In the journal PNAS this week, researchers at Boston Children's Hospital and MIT show that these mini-antibodies, shrunk further to create so-called nanobodies, may help solve a problem in the cancer field: making CAR T-cell therapies work in solid tumors. [14]
Category: Physics of Biology

[40] viXra:2002.0344 [pdf] submitted on 2020-02-18 05:09:02

Supramolecular Linkages

Authors: George Rajna
Comments: 25 Pages.

Supramolecular Linkages NUS biophysicists have developed a manipulation assay that can quantify the mechanical stability and biochemical regulations of inter-molecular interactions at the single-molecule level. [19] Now, a team of researchers led by Dongsheng Li, a materials scientist at PNNL, and collaborators at the University of Michigan and the Chinese Academy of Sciences, have unlocked the secret to one of the most useful nanostructures: the five-fold twin. [18] The researchers have generated femtosecond laser pulses, with tailor-made, temporally varying polarizations, which are themselves chiral. [17] The scientists identified a shortlist, a kind of "periodic table" of the most designable knot types, i.e. those knots that could easily self-assemble under appropriate physical and chemical conditions. [16] Scientists have now observed for the first time how diamonds grow from seed at an atomic level, and discovered just how big the seeds need to be to kick the crystal growing process into overdrive. [15] The researchers engineered diamond strings that can be tuned to quiet a qubit's environment and improve memory from tens to several hundred nanoseconds, enough time to do many operations on a quantum chip. [14] Intel has announced the design and fabrication of a 49-qubit superconducting quantum-processor chip at the Consumer Electronics Show in Las Vegas. To improve our understanding of the so-called quantum properties of materials, scientists at the TU Delft investigated thin slices of SrIrO3, a material that belongs to the family of complex oxides. [12] New research carried out by CQT researchers suggest that standard protocols that measure the dimensions of quantum systems may return incorrect numbers. [11] Is entanglement really necessary for describing the physical world, or is it possible to have some post-quantum theory without entanglement? [10] A trio of scientists who defied Einstein by proving the nonlocal nature of quantum entanglement will be honoured with the John Stewart Bell Prize from the University of Toronto (U of T). [9] While physicists are continually looking for ways to unify the theory of relativity, which describes large-scale phenomena, with quantum theory, which describes small-scale phenomena, computer scientists are searching for technologies to build the quantum computer using Quantum Information. In August 2013, the achievement of "fully deterministic" quantum teleportation, using a hybrid technique, was reported. On 29 May 2014, scientists announced a reliable way of transferring data by quantum teleportation. Quantum teleportation of data had been done before but with highly unreliable methods. The accelerating electrons explain not only the Maxwell Equations and the Special Relativity, but the Heisenberg Uncertainty Relation, the Wave-Particle Duality and the electron's spin also, building the Bridge between the Classical and Quantum Theories. The Planck Distribution Law of the electromagnetic oscillators explains the electron/proton mass rate and the Weak and Strong Interactions by the diffraction patterns. The Weak Interaction changes the diffraction patterns by moving the electric charge from one side to the other side of the diffraction pattern, which violates the CP and Time reversal symmetry. The diffraction patterns and the locality of the self-maintaining electromagnetic potential explains also the Quantum Entanglement, giving it as a natural part of the Relativistic Quantum Theory and making possible to build the Quantum Computer with the help of Quantum Information.
Category: Physics of Biology

[39] viXra:2002.0326 [pdf] submitted on 2020-02-17 04:40:30

CT Traces Coronavirus

Authors: George Rajna
Comments: 48 Pages.

An ongoing investigation into the novel coronavirus (2019-nCoV) outbreak has characterized the most common CT findings associated with the virus and identified possible markers of disease progression several days after the onset of symptoms. [27] To diagnose and treat diseases like cancer, scientists and doctors must understand how cells respond to different medical conditions and treatments. [26] Following its recent release of a massive database of chest X-rays, the US National Institutes of Health (NIH) has now made nearly 10,600 CT scans publicly available to support the development and testing of artificial intelligence (AI) algorithms for medical applications. [25] AI combined with stem cells promises a faster approach to disease prevention. Andrew Masterson reports. According to product chief Trystan Upstill, the news app "uses the best of artificial intelligence to find the best of human intelligence-the great reporting done by journalists around the globe." [23] Artificial intelligence is astonishing in its potential. It will be more transformative than the PC and the Internet. Already it is poised to solve some of our biggest challenges. [22] In the search for extraterrestrial intelligence (SETI), we've often looked for signs of intelligence, technology and communication that are similar to our own. [21] Call it an aMAZE -ing development: A U.K.-based team of researchers has developed an artificial intelligence program that can learn to take shortcuts through a labyrinth to reach its goal. In the process, the program developed structures akin to those in the human brain. [20] And as will be presented today at the 25th annual meeting of the Cognitive Neuroscience networks to enhance their understanding of one of the most elusive intelligence systems, the human brain. [19] U.S. Army Research Laboratory scientists have discovered a way to leverage emerging brain-like computer architectures for an age-old number-theoretic problem known as integer factorization. [18]
Category: Physics of Biology

[38] viXra:2002.0311 [pdf] submitted on 2020-02-16 01:49:17

Brain Cells for Human Vision

Authors: George Rajna
Comments: 51 Pages.

University of Central Florida researchers are helping to close the gap separating human and machine minds. [34] Brain-machine interfaces provide one way to connect with this puzzling organ system, including the brain. [33] Measuring optical blood flow in the resting human brain to detect spontaneous activity has for the first time been demonstrated by Wright State University imaging researchers, holding out promise for a better way to study people with autism, Alzheimer's and depression. [32]
Category: Physics of Biology

[37] viXra:2002.0310 [pdf] replaced on 2020-02-21 05:39:58

. Origin of New Emergent Coronavirus and Candida Fungal Diseases – Terrestrial or Cosmic?

Authors: Edward J. Steele, Jiangwen Qu, Reginald M. Gorczynski, Robyn A. Lindley, Gensuke Tokoro, Robert Temple, N. Chandra Wickramasinghe
Comments: 27 Pages.

We analyse the relevant genetic and epidemiological data of two recent and suddenly emerging diseases- the fungal disease due to Candida auris, and the common cold causing viral disease due to Coronavirus COVID-19. Analysis of all genetic, epidemiological and geophysical and astrophysical data suggest the alternate hypothesis of cosmic origins in both cases. The in-fall “signatures” are different yet distinctive implying clear Panspermic arrival of micro-organisms and viruses from space. For COVID-19 the evidence is now compelling that it arrived as a ‘pure culture’ via a meteorite, presumed carbonaceous meteorite, that struck North East China on October 11 2019. We also assume the viral dust debris carrying trillions of COVID-19 particles then made land fall in the Wuhan and related regions about a month to six weeks later. This resulted in first cases of the viral pneumonia due to COVID-19 emerging in Wuhan regions late November 2019-early December 2019. For COVID-19 the entire central region of China has been heavily physically contaminated, and that is why it has been described as a “Chernobyl-like” event. We make a number of future predictions – e.g. fragments of the meteorite viral dust cloud we think is now ( February 16 2020) on the move into the South China Sea and making spot land fall over Japan.
Category: Physics of Biology

[36] viXra:2002.0309 [pdf] submitted on 2020-02-16 03:53:40

Pancreatic Cancer Time Machine

Authors: George Rajna
Comments: 40 Pages.

A pancreatic cancer "time machine" engineered by Purdue University researchers has revealed that the disease is even more unpredictable than previously thought: Cancer cells promote each other's invasiveness when they grow together. [26] Kyoto University scientists are one step closer to designing porous materials that can change and retain their shapes-a function known as shape-memory effect. [25] With a thin probe and a burst of microwaves, doctors can eradicate cancer cells without opening up a patient for surgery. [24]
Category: Physics of Biology

[35] viXra:2002.0276 [pdf] submitted on 2020-02-14 08:12:07

Biomaterials Wound Healing

Authors: George Rajna
Comments: 42 Pages.

Biomaterials are used in the clinic as dressings that promote healing of wounds or burns. [24] Proteins rarely work alone, they interact, form protein complexes or bind DNA and RNA to control what a cell does. [23] Using tiny micromotors to diagnose and treat disease in the human body could soon be a reality. [22] Scientists at the University of Illinois at Urbana-Champaign have produced the most precise picture to date of population dynamics in fluctuating feast-or-famine conditions. [21]
Category: Physics of Biology

[34] viXra:2002.0272 [pdf] submitted on 2020-02-13 08:28:20

Nanosensor Cancer Biomarkers in Blood

Authors: George Rajna
Comments: 65 Pages.

Researchers of the University of Twente and Wageningen University developed a nanosensor that accurately detects biomarkers for cancer in an extremely broad range of concentrations, from 10 particles per microliter to 1 million particles per microliter. [37] Nanoparticles easily enter into cells. New insights about how they are distributed and what they do there are shown for the first time by high-resolution 3D microscopy images from BESSY II. [36] Johns Hopkins researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a "suicide gene" to pediatric brain tumor cells implanted in the brains of mice. [35]
Category: Physics of Biology

[33] viXra:2002.0257 [pdf] submitted on 2020-02-13 04:15:15

Nanoparticles Can Change Cells

Authors: George Rajna
Comments: 64 Pages.

Nanoparticles easily enter into cells. New insights about how they are distributed and what they do there are shown for the first time by high-resolution 3D microscopy images from BESSY II. [36] Johns Hopkins researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a "suicide gene" to pediatric brain tumor cells implanted in the brains of mice. [35] A new study at the University of Georgia has found a way to attack cancer cells that is potentially less harmful to the patient. [34]
Category: Physics of Biology

[32] viXra:2002.0242 [pdf] submitted on 2020-02-12 11:04:41

Nanoparticles Prevent Heart Attacks

Authors: George Rajna
Comments: 40 Pages.

An associate professor from Michigan State University has helped invent a potential treatment for coronary artery disease-a sub-microscopic scouring process he likens to "taking out the garbage." [23] Researchers at Oregon State University have developed an improved technique for using magnetic nanoclusters to kill hard-to-reach tumors. [22] MIT researchers have now come up with a novel way to prevent fibrosis from occurring, by incorporating a crystallized immunosuppressant drug into devices. [21] In a surprising marriage of science and art, researchers at MIT have developed a system for converting the molecular structures of proteins, the basic building blocks of all living beings, into audible sound that resembles musical passages. [20] Inspired by ideas from the physics of phase transitions and polymer physics, researchers in the Divisions of Physical and Biological Sciences at UC San Diego set out specifically to determine the organization of DNA inside the nucleus of a living cell. [19] Scientists from the National Institute of Standards and Technology (NIST) and the University of Maryland are using neutrons at Oak Ridge National Laboratory (ORNL) to capture new information about DNA and RNA molecules and enable more accurate computer simulations of how they interact with everything from proteins to viruses. [18] The DNA molecules are chiral, which means they can exist in two forms which are mirror images, like a left and right hand. The phenomenon was dubbed "chiral induced spin selectivity" (CISS), and over the last few years, several experiments were published allegedly showing this CISS effect, even in electronic devices. [17] Chemist Ivan Huc finds the inspiration for his work in the molecular principles that underlie biological systems. [16] What makes particles self-assemble into complex biological structures? [15] Scientists from Moscow State University (MSU) working with an international team of researchers have identified the structure of one of the key regions of telomerase-a so-called "cellular immortality" ribonucleoprotein. [14]
Category: Physics of Biology

[31] viXra:2002.0241 [pdf] submitted on 2020-02-12 11:22:53

Nanomaterial Transport to Cells

Authors: George Rajna
Comments: 74 Pages.

Bioengineers can design smart drugs for antibody and nanomaterial-based therapies to optimize drug efficiency for increasingly efficient, early-stage preclinical trials. [41] Many of these products use nanomaterials, but little is known about how these modern materials and their tiny particles interact with the environment and living things. [40] When chemists from the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw were starting work on a new material designed for the efficient production of nanocrystalline zinc oxide, they didn't expect any surprises. [39] Now writing in Light Science & Applications, Hamidreza Siampour and co-workers have taken a step forward in the field of integrated quantum plasmonics by demonstrating on-chip coupling between a single photon source and plasmonic waveguide. [38] Researchers at University of Utah Health developed a proof-of-concept technology using nanoparticles that could offer a new approach for oral medications. [37] Using scanning tunneling microscopy (STM), extremely high resolution imaging of the molecule-covered surface structures of silver nanoparticles is possible, even down to the recognition of individual parts of the molecules protecting the surface. [36] A fiber optic sensing system developed by researchers in China and Canada can peer inside supercapacitors and batteries to observe their state of charge. [35] The idea of using a sound wave in optical fibers initially came from the team's partner researchers at Bar-Ilan University in Israel. Joint research projects should follow. [34] Researchers at the Technion-Israel Institute of Technology have constructed a first-of-its-kind optic isolator based on resonance of light waves on a rapidly rotating glass sphere. [33] The micro-resonator is a two-mirror trap for the light, with the mirrors facing each other within several hundred nanometers. [32]
Category: Physics of Biology

[30] viXra:2002.0231 [pdf] submitted on 2020-02-12 04:15:58

Universal Target for Antiviral Treatment

Authors: George Rajna
Comments: 66 Pages.

As the coronavirus outbreak shows, viruses are a constant threat to humanity. Vaccines are regularly developed and deployed against specific viruses, but that process takes a lot of time, doesn't help everyone who needs protection, and still leaves people exposed to new outbreaks and new viruses. [39] It's no coincidence that some of the worst viral disease outbreaks in recent years-SARS, MERS, Ebola, Marburg and likely the newly arrived 2019-nCoV virus-originated in bats. [38] An interdisciplinary team of researchers at Colorado State University has used computational chemistry, biochemistry and virology to uncover new information on how viruses such as West Nile, dengue and Zika replicate. [37] David Baker, Professor of Biochemistry and Director of the Institute for Protein Design at the University of Washington will speak about how algorithmic processes such as de novo design predict protein structures, protein folding mechanisms, and new protein functions. [36] A research team at Kobe University has developed a method of artificially controlling the anchorage position of target proteins in engineered baker's yeast (Saccharomyces cerevisiae). [35] Scientists have found a new way to home in on the proteins covering a particular cell's surface. The feat offers insight into how brain cells form intricate networks during development. [34]
Category: Physics of Biology

[29] viXra:2002.0219 [pdf] submitted on 2020-02-11 04:09:49

Human Brain's Meticulous Interface

Authors: George Rajna
Comments: 40 Pages.

Now a team led by researchers at the Georgia Institute of Technology has engineered a way of studying the barrier more closely with the intent of helping drug developers do the same. In a new study, the researchers cultured the human blood-brain barrier on a chip, recreating its physiology more realistically than predecessor chips. [25]
Category: Physics of Biology

[28] viXra:2002.0214 [pdf] submitted on 2020-02-11 07:00:24

Coronavirus Outbreak Raises Question

Authors: George Rajna
Comments: 65 Pages.

It's no coincidence that some of the worst viral disease outbreaks in recent years-SARS, MERS, Ebola, Marburg and likely the newly arrived 2019-nCoV virus-originated in bats. [38] An interdisciplinary team of researchers at Colorado State University has used computational chemistry, biochemistry and virology to uncover new information on how viruses such as West Nile, dengue and Zika replicate. [37] David Baker, Professor of Biochemistry and Director of the Institute for Protein Design at the University of Washington will speak about how algorithmic processes such as de novo design predict protein structures, protein folding mechanisms, and new protein functions. [36] A research team at Kobe University has developed a method of artificially controlling the anchorage position of target proteins in engineered baker's yeast (Saccharomyces cerevisiae). [35] Scientists have found a new way to home in on the proteins covering a particular cell's surface. The feat offers insight into how brain cells form intricate networks during development. [34]
Category: Physics of Biology

[27] viXra:2002.0213 [pdf] submitted on 2020-02-11 09:59:37

Brain Temperature Measured by Light

Authors: George Rajna
Comments: 41 Pages.

Light could replace invasive techniques to measure brain temperature-eliminating the need to place a thermometer in the brain when treating a range of neurological disorders. [26] Now a team led by researchers at the Georgia Institute of Technology has engineered a way of studying the barrier more closely with the intent of helping drug developers do the same. In a new study, the researchers cultured the human blood-brain barrier on a chip, recreating its physiology more realistically than predecessor chips. [25]
Category: Physics of Biology

[26] viXra:2002.0210 [pdf] submitted on 2020-02-11 10:51:54

Muscular Dystrophy Diagnosis

Authors: George Rajna
Comments: 42 Pages.

Duchenne muscular dystrophy is the most common type of muscular dystrophy, affecting more than 10,000 males at birth per year in the United States with severe physical disability, chronic wasting and muscle deterioration. [27] Light could replace invasive techniques to measure brain temperature-eliminating the need to place a thermometer in the brain when treating a range of neurological disorders. [26] Now a team led by researchers at the Georgia Institute of Technology has engineered a way of studying the barrier more closely with the intent of helping drug developers do the same. In a new study, the researchers cultured the human blood-brain barrier on a chip, recreating its physiology more realistically than predecessor chips. [25]
Category: Physics of Biology

[25] viXra:2002.0207 [pdf] submitted on 2020-02-10 07:06:22

Light Removal of Medical Implants

Authors: George Rajna
Comments: 40 Pages.

A research team at the Massachusetts Institute of Technology (MIT) has designed medical devices that break down inside the body when they are exposed to light from an LED "pill". [25] An emerging technology involving tiny particles that absorb light and turn it into localized heat sources shows great promise in several fields, including medicine. [24] Two physicists from the University of Luxembourg have now unambiguously shown that quantum-mechanical wavelike interactions are indeed crucial even at the scale of natural biological processes. [23] Monika Aidelsburger uses a special type of optical lattice to simulate quantum many-body phenomena that are otherwise inaccessible to experimental exploration. [22] University of Illinois Professor Harry Hilton brought together several mathematical and physical theories to help look at problems in more unified ways and solve physical engineering problems. [21] A team of physicists from RUDN, JINR (Dubna), and the University of Hamburg (Germany) developed a mathematical model for describing physical processes in hybrid systems that consists of atoms and ions cooled down to temperatures close to absolute zero. [20] Recently, extensive study shows that the parity-time symmetry breaking in open systems leads to exceptional points, promising for novel applications leasers and sensing. [19] A recent discovery by William & Mary and University of Michigan researchers transforms our understanding of one of the most important laws of modern physics. [18] Now, a team of physicists from The University of Queensland and the NÉEL Institute has shown that, as far as quantum physics is concerned, the chicken and the egg can both come first. [17]
Category: Physics of Biology

[24] viXra:2002.0206 [pdf] submitted on 2020-02-10 07:23:02

Acid-Loving Microbe

Authors: George Rajna
Comments: 42 Pages.

Food and energy availability cause physical changes in acid-loving microorganisms that are used to study Earth's climate history, according to research from Dartmouth College. [26] A research team at the Massachusetts Institute of Technology (MIT) has designed medical devices that break down inside the body when they are exposed to light from an LED "pill". [25] An emerging technology involving tiny particles that absorb light and turn it into localized heat sources shows great promise in several fields, including medicine. [24] Two physicists from the University of Luxembourg have now unambiguously shown that quantum-mechanical wavelike interactions are indeed crucial even at the scale of natural biological processes. [23] Monika Aidelsburger uses a special type of optical lattice to simulate quantum many-body phenomena that are otherwise inaccessible to experimental exploration. [22] University of Illinois Professor Harry Hilton brought together several mathematical and physical theories to help look at problems in more unified ways and solve physical engineering problems. [21] A team of physicists from RUDN, JINR (Dubna), and the University of Hamburg (Germany) developed a mathematical model for describing physical processes in hybrid systems that consists of atoms and ions cooled down to temperatures close to absolute zero. [20] Recently, extensive study shows that the parity-time symmetry breaking in open systems leads to exceptional points, promising for novel applications leasers and sensing. [19]
Category: Physics of Biology

[23] viXra:2002.0205 [pdf] submitted on 2020-02-10 07:38:52

Repair Gaps in Damaged Nerves

Authors: George Rajna
Comments: 45 Pages.

A biodegradable nerve guide embedded with growth-promoting proteins that can regenerate long sections of damaged nerves has been developed by researchers in the US. [27] Food and energy availability cause physical changes in acid-loving microorganisms that are used to study Earth's climate history, according to research from Dartmouth College. [26] A research team at the Massachusetts Institute of Technology (MIT) has designed medical devices that break down inside the body when they are exposed to light from an LED "pill". [25] An emerging technology involving tiny particles that absorb light and turn it into localized heat sources shows great promise in several fields, including medicine. [24] Two physicists from the University of Luxembourg have now unambiguously shown that quantum-mechanical wavelike interactions are indeed crucial even at the scale of natural biological processes. [23] Monika Aidelsburger uses a special type of optical lattice to simulate quantum many-body phenomena that are otherwise inaccessible to experimental exploration. [22] University of Illinois Professor Harry Hilton brought together several mathematical and physical theories to help look at problems in more unified ways and solve physical engineering problems. [21] A team of physicists from RUDN, JINR (Dubna), and the University of Hamburg (Germany) developed a mathematical model for describing physical processes in hybrid systems that consists of atoms and ions cooled down to temperatures close to absolute zero. [20] Recently, extensive study shows that the parity-time symmetry breaking in open systems leads to exceptional points, promising for novel applications leasers and sensing. [19]
Category: Physics of Biology

[22] viXra:2002.0199 [pdf] submitted on 2020-02-10 10:02:17

Nanoparticles Carcinoma Prognosis

Authors: George Rajna
Comments: 46 Pages.

The paper explains how, thanks to their antioxidant and anti-inflammatory properties, cerium oxide nanoparticles have been able to partially reverse the cellular mechanisms involved in tumor progression and have managed to significantly increase survival in a rat animal model. [28] A biodegradable nerve guide embedded with growth-promoting proteins that can regenerate long sections of damaged nerves has been developed by researchers in the US. [27] Food and energy availability cause physical changes in acid-loving microorganisms that are used to study Earth's climate history, according to research from Dartmouth College. [26] A research team at the Massachusetts Institute of Technology (MIT) has designed medical devices that break down inside the body when they are exposed to light from an LED "pill". [25] An emerging technology involving tiny particles that absorb light and turn it into localized heat sources shows great promise in several fields, including medicine. [24] Two physicists from the University of Luxembourg have now unambiguously shown that quantum-mechanical wavelike interactions are indeed crucial even at the scale of natural biological processes. [23] Monika Aidelsburger uses a special type of optical lattice to simulate quantum many-body phenomena that are otherwise inaccessible to experimental exploration. [22] University of Illinois Professor Harry Hilton brought together several mathematical and physical theories to help look at problems in more unified ways and solve physical engineering problems. [21] A team of physicists from RUDN, JINR (Dubna), and the University of Hamburg (Germany) developed a mathematical model for describing physical processes in hybrid systems that consists of atoms and ions cooled down to temperatures close to absolute zero. [20]
Category: Physics of Biology

[21] viXra:2002.0195 [pdf] submitted on 2020-02-10 11:29:27

Nanosensors Detect Epileptic Seizures

Authors: George Rajna
Comments: 54 Pages.

Researchers at the Center for Nanoparticle Research, within the Institute for Basic Science (IBS, South Korea) in collaboration with collaborators at Zhejiang University, China, have reported a highly sensitive and specific nanosensor that can monitor dynamic changes of potassium ions in mice undergoing epileptic seizures, indicating their intensity and origin in the brain. [35] The lab of Cheryl Kerfeld at Michigan State University has created a synthetic nano-sized factory, based on natural ones found in bacteria. [34]
Category: Physics of Biology

[20] viXra:2002.0177 [pdf] submitted on 2020-02-09 02:11:18

Proteins from Scratch

Authors: George Rajna
Comments: 59 Pages.

David Baker, Professor of Biochemistry and Director of the Institute for Protein Design at the University of Washington will speak about how algorithmic processes such as de novo design predict protein structures, protein folding mechanisms, and new protein functions. [36] A research team at Kobe University has developed a method of artificially controlling the anchorage position of target proteins in engineered baker's yeast (Saccharomyces cerevisiae). [35]
Category: Physics of Biology

[19] viXra:2002.0176 [pdf] submitted on 2020-02-09 02:29:52

Protein Puts Brakes on Virus Replication

Authors: George Rajna
Comments: 61 Pages.

An interdisciplinary team of researchers at Colorado State University has used computational chemistry, biochemistry and virology to uncover new information on how viruses such as West Nile, dengue and Zika replicate. [37] David Baker, Professor of Biochemistry and Director of the Institute for Protein Design at the University of Washington will speak about how algorithmic processes such as de novo design predict protein structures, protein folding mechanisms, and new protein functions. [36] A research team at Kobe University has developed a method of artificially controlling the anchorage position of target proteins in engineered baker's yeast (Saccharomyces cerevisiae). [35]
Category: Physics of Biology

[18] viXra:2002.0173 [pdf] submitted on 2020-02-09 03:45:26

Gene Therapies Options

Authors: George Rajna
Comments: 62 Pages.

Now, a team of scientists from Purdue University and other research institutions around the world have come together to better understand the growing number of worldwide patented innovations available for gene therapy treatment. [38] An interdisciplinary team of researchers at Colorado State University has used computational chemistry, biochemistry and virology to uncover new information on how viruses such as West Nile, dengue and Zika replicate. [37] David Baker, Professor of Biochemistry and Director of the Institute for Protein Design at the University of Washington will speak about how algorithmic processes such as de novo design predict protein structures, protein folding mechanisms, and new protein functions. [36] A research team at Kobe University has developed a method of artificially controlling the anchorage position of target proteins in engineered baker's yeast (Saccharomyces cerevisiae). [35] Scientists have found a new way to home in on the proteins covering a particular cell's surface. The feat offers insight into how brain cells form intricate networks during development. [34]
Category: Physics of Biology

[17] viXra:2002.0172 [pdf] submitted on 2020-02-09 04:01:40

Females Second X Chromosomes

Authors: George Rajna
Comments: 64 Pages.

Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg and Institut Curie in Paris have shown that the protein SPEN plays a crucial role in the process of X-chromosome inactivation, whereby female mammalian embryos silence gene expression on one of their two X chromosomes. [39] Now, a team of scientists from Purdue University and other research institutions around the world have come together to better understand the growing number of worldwide patented innovations available for gene therapy treatment. [38] An interdisciplinary team of researchers at Colorado State University has used computational chemistry, biochemistry and virology to uncover new information on how viruses such as West Nile, dengue and Zika replicate. [37] David Baker, Professor of Biochemistry and Director of the Institute for Protein Design at the University of Washington will speak about how algorithmic processes such as de novo design predict protein structures, protein folding mechanisms, and new protein functions. [36] A research team at Kobe University has developed a method of artificially controlling the anchorage position of target proteins in engineered baker's yeast (Saccharomyces cerevisiae). [35] Scientists have found a new way to home in on the proteins covering a particular cell's surface. The feat offers insight into how brain cells form intricate networks during development. [34]
Category: Physics of Biology

[16] viXra:2002.0171 [pdf] submitted on 2020-02-09 04:33:14

Bioprinting Research

Authors: George Rajna
Comments: 63 Pages.

Published today in IOP Publishing's Biofabrication, leading researchers define the status, challenges and opportunities in the field, and forecast the required advances in science & technology to overcome the challenges to a range of bioprinting techniques and applications. [43] Scientists from the University of Groningen (the Netherlands) and the University of Würzburg (Germany) have investigated a simple biomimetic light-harvesting system using advanced spectroscopy combined with a microfluidic platform. [42] Gallium nitride, a semiconductor that revolutionized energy-efficient LED lighting, could also transform electronics and wireless communication, thanks to a discovery made by Cornell researchers. [41]
Category: Physics of Biology

[15] viXra:2002.0158 [pdf] submitted on 2020-02-08 04:31:35

Nanoparticles in Mice Lungs

Authors: George Rajna
Comments: 56 Pages.

Virginia Tech scientists have discovered that incredibly small particles of an unusual and highly toxic titanium oxide found in coal smog and ash can cause lung damage in mice after a single exposure, with long-term damage occurring in just six weeks. [37] Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer's disease, Parkinson's disease, other neurodegenerative diseases and central nervous system injuries. [36] Tiny silica bottles filled with medicine and a special temperature-sensitive material could be used for drug delivery to kill malignant cells only in certain parts of the body, according to a study published recently by researchers at the Georgia Institute of Technology. [35]
Category: Physics of Biology

[14] viXra:2002.0156 [pdf] submitted on 2020-02-08 05:17:19

Artificial Virus Against Superbugs

Authors: George Rajna
Comments: 43 Pages.

Scientists at NPL, working with partners from the University of Cambridge, University of Exeter, King's College London and University College London have developed a mechanism of antibacterial persistence to combat persistent and resistant bacterial infections. [31] The fight against global antibiotic resistance has taken a major step forward with scientists discovering a concept for fabricating nanomeshes as an effective drug delivery system for antibiotics. [30] The solution consisting of colloidal quantum dots is inkjet-printed, creating active photosensitive layer of the photodetector. [29] I'm part of a group of nanotechnology and neuroscience researchers at the University of Washington investigating how quantum dots behave in the brain. [28] Nanotechnology may provide an effective treatment for Parkinson's disease, a team of researchers suggests. [27] Recent research from Kumamoto University in Japan has revealed that polyoxometalates (POMs), typically used for catalysis, electrochemistry, and photochemistry, may also be used in a technique for analyzing quantum dot (QD) photoluminescence (PL) emission mechanisms. [26] Researchers have designed a new type of laser called a quantum dot ring laser that emits red, orange, and green light. [25] The world of nanosensors may be physically small, but the demand is large and growing, with little sign of slowing. [24] In a joint research project, scientists from the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy (MBI), the Technische Universität Berlin (TU) and the University of Rostock have managed for the first time to image free nanoparticles in a laboratory experiment using a highintensity laser source. [23] For the first time, researchers have built a nanolaser that uses only a single molecular layer, placed on a thin silicon beam, which operates at room temperature. [22] A team of engineers at Caltech has discovered how to use computer-chip manufacturing technologies to create the kind of reflective materials that make safety vests, running shoes, and road signs appear shiny in the dark. [21]
Category: Physics of Biology

[13] viXra:2002.0118 [pdf] replaced on 2020-02-09 04:24:46

The Coronavirus May Have Come From Space

Authors: N Chandra Wickramasinghe, Edward J Steele
Comments: 7 Pages.

With a new coronavirus making the headlines and causing personal distress to many and extending its realm of havoc into the financial and business world the truest cause of this and other similar pandemics needs to be honestly explored. All the epidemiological, genetic, geophysical and astrophysical data are consistent with a cause associated with a meteorite explosion in North East China on October 11 2019. The sequelae of events following this event are put in historical context of pestilence and disease episodes following similar events throughout recorded human history.
Category: Physics of Biology

[12] viXra:2002.0113 [pdf] submitted on 2020-02-06 07:59:41

Ultrasound Selectively Kill Cancer Cells

Authors: George Rajna
Comments: 64 Pages.

A new technique could offer a targeted approach to fighting cancer: low-intensity pulses of ultrasound have been shown to selectively kill cancer cells while leaving normal cells unharmed. [34] Doctors have used focused ultrasound to destroy tumors without invasive surgery for some time. However, the therapeutic ultrasound used in clinics today indiscriminately damages cancer and healthy cells alike. [33] Scientists in the UK have shown for the first time that focused ultrasound from outside the body can improve the delivery of cancer drugs to tumors in humans. [32] The discovery could help us better understand aging and eventually could lead to new treatments for cancer. [31] A research team at the University of Delaware, led by Emily Day, an assistant professor of biomedical engineering, is laying the groundwork for a method to inhibit cancer-promoting genes in cancer cells while leaving healthy cells intact. [30] Researchers have moved closer to the real-time verification of hadron therapy, demonstrating the in vivo accuracy of simulations that predict particle range in the patient. [29] A biomimetic nanosystem can deliver therapeutic proteins to selectively target cancerous tumors, according to a team of Penn State researchers. [28] Sunlight is essential for all life, and living organisms have evolved to sense and respond to light. [27] Using X-ray laser technology, a team led by researchers of the Paul Scherrer Institute PSI has recorded one of the fastest processes in biology. [26] A Virginia Commonwealth University researcher has developed a procedure for identifying the source of cells present in a forensic biological sample that could change how cell types are identified in samples across numerous industries. [25] In work at the National Institute of Standards and Technology (NIST) and the University of Maryland in College Park, researchers have devised and demonstrated a new way to measure free energy. [24]
Category: Physics of Biology

[11] viXra:2002.0093 [pdf] submitted on 2020-02-05 05:16:44

X-Ray Tuberculosis and Osteoporosis

Authors: George Rajna
Comments: 34 Pages.

With an advanced X-ray combination technique, scientists have traced nanocarriers for tuberculosis drugs within cells with very high precision. [20] Now an international team of researchers has found a new way to investigate how Tb bacteria inactivate an important family of antibiotics: They watched the process in action for the first time using an X-ray free-electron laser, or XFEL. [19] A protein complex called facilitates chromatin transcription (FACT) plays a role in DNA packing within a nucleus, as well as in oncogenesis. [18]
Category: Physics of Biology

[10] viXra:2002.0091 [pdf] submitted on 2020-02-05 05:33:07

Motor-Related Brain Activity

Authors: George Rajna
Comments: 48 Pages.

Motor-related brain activity, particularly its accurate detection, quantification and classification capabilities, is of great interest to researchers. [33] Measuring optical blood flow in the resting human brain to detect spontaneous activity has for the first time been demonstrated by Wright State University imaging researchers, holding out promise for a better way to study people with autism, Alzheimer's and depression. [32] UCLA biologists report they have transferred a memory from one marine snail to another, creating an artificial memory, by injecting RNA from one to another. [31]
Category: Physics of Biology

[9] viXra:2002.0082 [pdf] submitted on 2020-02-05 09:13:41

DNA-Based Nanorobot Cancer Diagnostics

Authors: George Rajna
Comments: 65 Pages.

A group of researchers from ITMO University has come up with the concept of a new drug against cancer: a nanorobot made of DNA fragments, which can potentially be used not only to destroy cancer cells, but also to locate them in the body. [40] A team of researchers at the Hebrew University of Jerusalem in Israel has now made such cascades in the lab by encapsulating three enzymes and enzyme cofactors in nanoreactors made from metal-organic framework nanoparticles. [39] Researchers have developed a new form of nanoparticle and associated imaging technique that can detect multiple disease biomarkers, including those for breast cancer, found in deep-tissue in the body. [38] Researchers at University of Utah Health developed a proof-of-concept technology using nanoparticles that could offer a new approach for oral medications. [37] Using scanning tunneling microscopy (STM), extremely high resolution imaging of the molecule-covered surface structures of silver nanoparticles is possible, even down to the recognition of individual parts of the molecules protecting the surface. [36] A fiber optic sensing system developed by researchers in China and Canada can peer inside supercapacitors and batteries to observe their state of charge. [35] The idea of using a sound wave in optical fibers initially came from the team's partner researchers at Bar-Ilan University in Israel. Joint research projects should follow. [34] Researchers at the Technion-Israel Institute of Technology have constructed a first-of-its-kind optic isolator based on resonance of light waves on a rapidly rotating glass sphere. [33] The micro-resonator is a two-mirror trap for the light, with the mirrors facing each other within several hundred nanometers. [32]
Category: Physics of Biology

[8] viXra:2002.0080 [pdf] submitted on 2020-02-05 09:42:22

Nanoparticles Trick Kidney

Authors: George Rajna
Comments: 66 Pages.

"Our nature-inspired approach enabled us to trick the kidney environment to let nanoparticles pass through," adds Dr. Melika Sarem who was a co-author of the study. [41] A group of researchers from ITMO University has come up with the concept of a new drug against cancer: a nanorobot made of DNA fragments, which can potentially be used not only to destroy cancer cells, but also to locate them in the body. [40] A team of researchers at the Hebrew University of Jerusalem in Israel has now made such cascades in the lab by encapsulating three enzymes and enzyme cofactors in nanoreactors made from metal-organic framework nanoparticles. [39] Researchers have developed a new form of nanoparticle and associated imaging technique that can detect multiple disease biomarkers, including those for breast cancer, found in deep-tissue in the body. [38] Researchers at University of Utah Health developed a proof-of-concept technology using nanoparticles that could offer a new approach for oral medications. [37] Using scanning tunneling microscopy (STM), extremely high resolution imaging of the molecule-covered surface structures of silver nanoparticles is possible, even down to the recognition of individual parts of the molecules protecting the surface. [36] A fiber optic sensing system developed by researchers in China and Canada can peer inside supercapacitors and batteries to observe their state of charge. [35] The idea of using a sound wave in optical fibers initially came from the team's partner researchers at Bar-Ilan University in Israel. Joint research projects should follow. [34] Researchers at the Technion-Israel Institute of Technology have constructed a first-of-its-kind optic isolator based on resonance of light waves on a rapidly rotating glass sphere. [33] The micro-resonator is a two-mirror trap for the light, with the mirrors facing each other within several hundred nanometers. [32]
Category: Physics of Biology

[7] viXra:2002.0079 [pdf] submitted on 2020-02-05 10:10:16

Bone's Electricity Promote Regeneration

Authors: George Rajna
Comments: 67 Pages.

Some materials show promise promoting bone regeneration by enhancing its natural electrical properties, according to a review in the journal Science and Technology of Advanced Materials. [42] "Our nature-inspired approach enabled us to trick the kidney environment to let nanoparticles pass through," adds Dr. Melika Sarem who was a co-author of the study. [41] A group of researchers from ITMO University has come up with the concept of a new drug against cancer: a nanorobot made of DNA fragments, which can potentially be used not only to destroy cancer cells, but also to locate them in the body. [40] A team of researchers at the Hebrew University of Jerusalem in Israel has now made such cascades in the lab by encapsulating three enzymes and enzyme cofactors in nanoreactors made from metal-organic framework nanoparticles. [39] Researchers have developed a new form of nanoparticle and associated imaging technique that can detect multiple disease biomarkers, including those for breast cancer, found in deep-tissue in the body. [38] Researchers at University of Utah Health developed a proof-of-concept technology using nanoparticles that could offer a new approach for oral medications. [37] Using scanning tunneling microscopy (STM), extremely high resolution imaging of the molecule-covered surface structures of silver nanoparticles is possible, even down to the recognition of individual parts of the molecules protecting the surface. [36] A fiber optic sensing system developed by researchers in China and Canada can peer inside supercapacitors and batteries to observe their state of charge. [35] The idea of using a sound wave in optical fibers initially came from the team's partner researchers at Bar-Ilan University in Israel. Joint research projects should follow. [34]
Category: Physics of Biology

[6] viXra:2002.0059 [pdf] submitted on 2020-02-04 06:48:07

Cellular Transport System

Authors: George Rajna
Comments: 40 Pages.

Bulky globular proteins require specialized transport systems for insertion into membranes. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have determined the structure of such a system for the first time, and propose that it exploits the principle of the airlock. [30] One of the main challenges in tissue engineering today is to create a complete network of blood vessels and capillaries throughout an artificial tissue. [29] Scientists from the University of Freiburg have developed materials systems that are composed of biological components and polymer materials and are capable of perceiving and processing information. [28]
Category: Physics of Biology

[5] viXra:2002.0039 [pdf] replaced on 2020-02-05 01:30:58

Comment on the Origin of the 2019 Novel Coronavirus

Authors: Edward J. Steele, N. Chandra Wickramasinghe, Jiangwen Qu, Robert Temple, Gensuke Tokoro, Reginald M. Gorczynski
Comments: 5 Pages.

Analysis of all genetic, epidemiological and geophysical and astrophysical data suggest the alternate hypothesis that nCoV-2019 arrived via a meteorite, presumed carbonaceous meteorite, that struck North East China on October 11 2019. We then assume the viral debris and particles then made land fall in the Wuhan and related regions about a month to six weeks later resulting in first cases of the viral pneumonia caused by nCoV-2019 emerging in Wuhan regions late November 2019-early December 2019.
Category: Physics of Biology

[4] viXra:2002.0033 [pdf] submitted on 2020-02-03 05:33:42

Tumor Hypoxia During Radiotherapy

Authors: George Rajna
Comments: 54 Pages.

Tumour hypoxia, defined as low levels of oxygen partial pressure (pO2), can cause resistance to radiotherapy. [33] “Identifying tissues not only by their structure and morphology, as is done today, but also by their unique molecular signatures can assist in diagnosis and decision-making,” says lead author Alexander Golberg, professor of environment and earth sciences at Tel Aviv University. [32] A particularly aggressive, metastasizing form of cancer, HER2-positive breast cancer, may be treated with nanoscopic particles "imprinted" with specific binding sites for the receptor molecule HER2. [31]
Category: Physics of Biology

[3] viXra:2002.0032 [pdf] submitted on 2020-02-03 07:09:03

Microbiome Using RNA Sequencing

Authors: George Rajna
Comments: 39 Pages.

A new collaborative study published by a research team from the Wayne State University School of Medicine, the CReATe Fertility Centre and the University of Massachusetts Amherst provides the first in-depth look at the microbiome of human sperm utilizing RNA sequencing with sufficient sensitivity to identify contamination and pathogenic bacterial colonization. [25] An LMU team has improved both the sensitivity and efficiency of a popular method for single-cell RNA sequencing, which yields a molecular fingerprint for individual cells based on their patterns of gene activity. [24] The goal is to find bits of DNA in common between the known relatives and the unidentified remains, suggesting both belong to a particular lineage. One analysis develops a profile that combines what's found at 23 spots in the DNA, for example. [23] A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions. [22]
Category: Physics of Biology

[2] viXra:2002.0031 [pdf] submitted on 2020-02-03 07:42:23

Synthesis of Antitumor Compounds

Authors: George Rajna
Comments: 55 Pages.

RUDN chemist Viktor Khrustalev and his colleagues developed a method for the synthesis of isomers of these substances, that is, the compounds that are identical in atomic composition but different in the arrangement of atoms in space. [34] Tumour hypoxia, defined as low levels of oxygen partial pressure (pO2), can cause resistance to radiotherapy. [33] “Identifying tissues not only by their structure and morphology, as is done today, but also by their unique molecular signatures can assist in diagnosis and decision-making,” says lead author Alexander Golberg, professor of environment and earth sciences at Tel Aviv University. [32]
Category: Physics of Biology

[1] viXra:2002.0030 [pdf] submitted on 2020-02-03 07:58:48

Enzyme Fight Cancer Cells

Authors: George Rajna
Comments: 56 Pages.

A RUDN University biochemist has studied the stimulating effect of chemical substances on the catabolic enzyme PAO (polyamine oxidase). The results could contribute to the development of drugs against cancer. [35] RUDN chemist Viktor Khrustalev and his colleagues developed a method for the synthesis of isomers of these substances, that is, the compounds that are identical in atomic composition but different in the arrangement of atoms in space. [34] Tumour hypoxia, defined as low levels of oxygen partial pressure (pO2), can cause resistance to radiotherapy. [33] "Identifying tissues not only by their structure and morphology, as is done today, but also by their unique molecular signatures can assist in diagnosis and decision-making," says lead author Alexander Golberg, professor of environment and earth sciences at Tel Aviv University. [32] A particularly aggressive, metastasizing form of cancer, HER2-positive breast cancer, may be treated with nanoscopic particles "imprinted" with specific binding sites for the receptor molecule HER2. [31] UNC School of Medicine scientists created a powerful new "directed evolution" technique for the rapid development of scientific tools and new treatments for many diseases. [30] Scientists have been aware of this 'length problem' for a long time, but it was largely overlooked for most of the twentieth century. [29] Such emulsions are similar to the mixture that forms when you shake an oil-and-vinegar salad dressing, but with much smaller droplets. [28] Russian scientists found that nanocrystal tungsten trioxide can be used instead of barium for X-ray examinations and also in cancer treatment. [27] Medical advancements can come at a physical cost. Often following diagnosis and treatment for cancer and other diseases, patients' organs and cells can remain healed but damaged from the medical condition. [26]
Category: Physics of Biology