Chemistry

   

Antibacterial Activity of Some Newer 1,2,3 – Benzotriazole Derivatives Synthesized by Ultrasonication in Solvent – Free Conditions

Authors: S.S. Muvvala1, V.N. Ratnakaram

Many of the classical synthetic methodologies have broad scope but generate copious amounts of waste. The chemical and pharmaceutical industries have been subjected to increasing pressure to minimize or, preferably, eliminate this waste. In the present study a series of some newer 1,2,3–benzotriazole derivatives were synthesized under ultrasonicated and solvent–free conditions. Newer “1–(1H–benzo[d][1,2,3]triazole–1–carbonyl) derivatives” (5A – 5P) were synthesized from “1H–benzo[d][1,2,3]triazole” (1) by optimizing the reaction conditions. The resulting products were isolated and characterized by spectral studies. The anti bacterial activities of these compounds were screened in vitro against different strains of bacteria i.e. Gram negative organism (Pseudonomous aureginosa, MTCC – 1035) and Gram positive organisms (Bacillus cereus, MTCC – 430, Bacillus subtilis, MTCC – 441, Staphylococcus aureus, MTCC – 737, Staphylococcus epidermidis, MTCC – 3086) by paper disc diffusion method. Some of the synthesized compounds showed significant activity against various bacteria.

Comments: 6 Pages. OK

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[v1] 2019-05-19 05:33:49

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