Quantitative Biology

1302 Submissions

[3] viXra:1302.0092 [pdf] submitted on 2013-02-13 17:20:12

A Theoretical Solution for Ventricular Septal Defects And Pulmonary Vein Stenosis

Authors: Alan Williams
Comments: 5 Pages.

Ventricular Septal Defects (VSD) and Pulmonary Vein Stenosis (PVS) are both normally non- life- threatening problems for survivors of early childhood. However, it can be a large hindrance to many patients who want a normal life. With this proposed solution, patients should be able to achieve a life mostly free of problems. Hopefully, only regular check-ups will be required after the initial treatment.
Category: Quantitative Biology

[2] viXra:1302.0078 [pdf] submitted on 2013-02-12 22:32:18

Spnb2 Protein Family Architecture Perspective and Differences in Complex Form of Exon/intron Usage

Authors: Mark R. Brenneman
Comments: 1 Page. emissrto@yahoo.com

Spectrin isoforms are found in erythroid and nonerythroid cells. Spectrin is a component (known as the postsynaptic density (PSD)) for the maintenance of cell cytoskeleton shape the main fibrous component of which is spectrin of the erythrocyte membrane controlling Smad3/4 subcellular localization in TGFβ/Smad signalling resulting in nuclear translocation of activated Smad4. beta subunit-fodrin, spectrin-like protein, is a nonerythroid spectrin analogue alpha Spna-1 related to human erythrocytic 1 (hSPTBN1) Nonerythroid brain spectrin (Spnb-2 Beta-II spectrin). Three isoforms of brain spectrin contains three structural domains. A nonerythroid 9 Kb mRNA which encodes neuronal beta SpIIa occurs also in neonatal cardiomyocytes with ankyrin-B and ELF (Spnb-2), a new isoform of beta-G-spectrin. Spnb2 js found to cross-react with human erythrocyte beta subunit spectrin-ankyrin scaffold in restoring similarity of structure to lateral membrane biogenesis, cross-linking protein alpha-chain, and the Actin binding N-terminal domain of beta-chain, a form of exon/intron usage of two antiparallel dimers usage Complementary DNA synthesized from a messenger mRNA a stem cell adaptor protein is found in two to four cells per 30,000-50,000 cells.
Category: Quantitative Biology

[1] viXra:1302.0027 [pdf] submitted on 2013-02-04 16:39:12

On the K-Mer Frequency Spectra of Organism Genome and Proteome Sequences with a Preliminary Machine Learning Assessment of Prime Predictability

Authors: Nathan O. Schmidt
Comments: 130 pages and 18 figures

A regular expression and region-specific filtering system for biological records at the National Center for Biotechnology database is integrated into an object-oriented sequence counting application, and a statistical software suite is designed and deployed to interpret the resulting k-mer frequencies---with a priority focus on nullomers. The proteome k-mer frequency spectra of ten model organisms and the genome k-mer frequency spectra of two bacteria and virus strains for the coding and non-coding regions are comparatively scrutinized. We observe that the naturally-evolved (NCBI/organism) and the artificially-biased (randomly-generated) sequences exhibit a clear deviation from the artificially-unbiased (randomly-generated) histogram distributions. Furthermore, a preliminary assessment of prime predictability is conducted on chronologically ordered NCBI genome snapshots over an 18-month period using an artificial neural network; three distinct supervised machine learning algorithms are used to train and test the system on customized NCBI data sets to forecast future prime states---revealing that, to a modest degree, it is feasible to make such predictions.
Category: Quantitative Biology